Hyperphosphorylation of the tau protein (tau inclusions, pTau) can result in the self-assembly of tangles of paired helical filaments and straight filaments, which are involved in the pathogenesis of Alzheimer's disease, frontotemporal dementia, and other
Check-out this comparison graphic of a diseased vs.
6 Big Mysteries of Alzheimer's Disease
THE MYSTERIES OF ALZHEIMER'S Alzheimer's disease is a slowly progressing brain disorder. In people with the condition, abnormal deposits of a protein called amyloid-beta forms sticky plaques in the brain, and strands of the protein tau twist around, causing tangles that ultimately kill brain cells and cause a loss of memory, thinking and reasoning skills.
Toxic form of tau protein foils memory formation in Alzheimer’s. Study in mice provides a mechanism for how the notorious protein stops neurons from strengthening their connections – and how we form memories