Biscuit-Topped Ground Beef Casserole - Biscuit-Topped Ground Beef Casserole is a glorious ground beef casserole. The ground beef mixture is sandwiched between the top and bottom half of homemade biscuits. It's great comfort food that's especially good in the winter, when it's cold outside. Don't be scared off by the term "homemade biscuits". They're not difficult to make. Both children and adults will go back for seconds.